8/10/2023 0 Comments Ts moca houstonEndogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta-2 integrin gene expression. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. Eltzschig is among the highest-cited physician-scientists from the field of perioperative medicine. With an H-index of 97 and over 34,700 citations, Dr. Moreover, he published review papers in Nature, Nature Medicine, Nature Reviews Cardiology, Blood, and Anesthesiology and three review papers in Nature Reviews Drug Discovery that focus on his research findings. Eltzschig is the lead author of three review papers published in the New England Journal of Medicine. Eltzschig has published over 320 peer-reviewed research contributions, including first or senior-author papers in Nature Medicine, Nature Immunology, Circulation, Gastroenterology, Gut, Science Translational Medicine, The Journal of Clinical Investigations, The Journal of Experimental Medicine, PLoS Medicine, PLoS Biology, Circulation Research, Blood, PNAS, Nature Communications, and many other leading biomedical journals. Our recent study found that an increase of adenosine levels in experimental colitis might exploit protective adenosine receptor signaling.ĭr. Numerous studies suggest that one of the key elements in inflammatory bowel diseases (IBD) is dysfunction of intestinal epithelial barrier function caused by intestinal inflammation. We hope that our findings could support the potentials of proton pump inhibitors as therapeutic options to prevent or treat AKI. Our recent studies suggested that genetic deletion or pharmacologic inhibition of the renal proton pump ATP4A with proton pump inhibitors conveys very potent renal protection. Our recent studies showed that changes in metabolic supply and demand lead to the stabilization of hypoxia-inducible transcription factors during myocardial ischemia, resulting in upregulation of cardio-protective small molecules, such as epithelial growth factor amphiregulin (AREG).Īcute kidney injury (AKI) is a leading cause of morbidity and mortality of perioperative patients, and therapeutic approaches to prevent or treat AKI are limited. We are also interested in understanding cardio-protective mechanisms and targets during the Myocardial Ischemia/Reperfusion (IR) injury. Our recent studies of lung injuries focus on investigating the role of hypoxia-inducible factors (HIFs) and microRNAs in the underlying mechanisms of ALI. The research in the lung group focuses on understanding the inflammatory responses in acute lung injuries, including ventilation induced lung injury (VILI) and LPS-induced lung injury. It is hoped that these studies contribute to novel pharmacologic approaches to prevent or treat acute organ injury in surgical patients. These molecular concepts have been applied to a wide range of disease models that are important for the field of anesthesiology, critical care, and perioperative medicine, including acute lung injury, myocardial or hepatic ischemia, acute kidney injury, and intestinal inflammation. The Eltzschig laboratory is interested in studying endogenous adaptive pathways that are under the control of hypoxia-inducible factors.
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